To install, just extract the dinput8.dll file from the ZIP into your Resident Evil Requiem installation folder.

You can open the menu by pressing the Insert key.

Scripts should be placed in the “reframework/autorun” folder.
Plugins should go in the “reframework/plugins” folder. You can also load standalone DLL files there even if they do not use REF functionality.

If REFramework cannot access the current game directory for any reason, it will use “%APPDATA%/REFramework” for all of its files instead.
In that situation, scripts and plugins will need to be placed there.

To temporarily uninstall REFramework, just remove the dinput8.dll file from your game directory.
To completely remove it along with all mods, you will also need to delete the reframework folder, re2_fw_config.txt, re2_framework_log.txt, and reframework_crash.dmp if it exists.